Injection Lipolysis with a Cocktail of Phosphatidylcholine and Deoxycholate: An Indian Experience

1 Sir: I view of recent United States Food and Drug Administration (USFDA) approval of deoxycholate (DC) as a constituent for lipolysis,1 we would like to share our experience of using it in combination with phosphatidylcholine (PC) for injection lipolysis. PC and DC have independently been used in lipolysis and are both USFDA approved; however, a combination of both has not been approved by the USFDA. DC is a bile salt and fundamentally increases the solubility of PC, which is structurally a phospholipid.2 The first use of this class of drugs was done to dissolve the intramural accumulations of atherosclerotic plaques in systemic arteries and was later followed by usage to treat the pulmonary fat embolism. We have been using the combination since 2004 and have had good results in 956 patients so far. We have used the PC-DC mixture in varied age groups, both sexes, and over different target areas. The amount injected per site was about 50% less on the face when compared to any other body part, and the amount injected at each prick was not more than 0.3 cc. The maximum dose used in 1 sitting is 5 g and the minimum interval between 2 subsequent sittings we followed has been 4 weeks. The maximal appreciable effect is achieved in 80% of patients by day 10; however, the drug continues to act for 6–8 weeks. The effects are more easily appreciated over the face (malar and submental areas) and arms and show average effects in the back and around the knees. We have also used lipolysis as primary modality and a touch-up modality following liposuction. The results are better appreciated in primary lipolysis. The need for follow-up sessions (1–2 sessions) of lipolysis and the quantification of results in subsequent sessions reveal that maximal improvement is achieved in the first session. We have also successfully used this technique of lipolysis in post free fat grafting cases, where patient desired minimal undercorrection subsequent to fat hypertrophy. The injection sites are guided by a custom-made predesigned grid, which ensures that the injections are adequately spaced, and the projected cone of lipolysis has a minimal overlap ensuring a smoother transition into zone of neighboring injection (Fig. 1). The most common complaint after the procedure is a stinging type of a pain. Other complaints after the procedure were erythema, edema, induration, and formation of subcutaneous nodules, which resolved over a period of time. Accidental injection into the muscle causes Injection Lipolysis with a Cocktail of Phosphatidylcholine and Deoxycholate: An Indian Experience